AurB/C anticorps (N-Term)

N° du produit ABIN6260157

L’anticorps anti-AurB/C Polyclonal Lapin est utilisé pour la détection de AurB/C dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour AurB/C anticorps (N-Term) (ABIN6260157)

Antigène: AurB/C (AURKB/C) (Aurora Kinase B/C (AURKB/C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AurB/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-AurB/C anticorps

Épitope: N-Term

Fonction: AurB/C Antibody

Specificité: AurB/C Antibody detects endogenous levels of total AurB/C.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human AurB/C, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200,WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur AurB/C

Antigène: AurB/C (AURKB/C) (Aurora Kinase B/C (AURKB/C))

Autre désignation: AurB/C

Sujet:

Description: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

Gene: AURKC

Poids moléculaire: 36 kDa

ID gène: 6795

UniProt: Q9UQB9