Claspin anticorps (N-Term)

N° du produit ABIN6260859

Détail du produit anti-Claspin anticorps

Antigène: Claspin (CLSPN)

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claspin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: Claspin Antibody detects endogenous levels of total Claspin.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Claspin, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Claspin

Antigène: Claspin (CLSPN)

Autre désignation: CLSPN (CLSPN Produits)

Synonymes: anticorps CLSPN, anticorps xClaspin, anticorps B130025E01, anticorps C85083, anticorps E130314M08Rik, anticorps claspin, anticorps claspin S homeolog, anticorps Clspn, anticorps CLSPN, anticorps clspn, anticorps clspn.S

Sujet:

Description: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Gene: CLSPN

Poids moléculaire: 150 kDa

ID gène: 63967

UniProt: Q9HAW4