TPX2 anticorps (C-Term)

N° du produit ABIN6261299

Détail du produit anti-TPX2 anticorps

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: DIL-2 Antibody detects endogenous levels of total DIL-2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DIL-2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TPX2

Antigène: TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))

Autre désignation: TPX2 (TPX2 Produits)

Synonymes: anticorps C20orf1, anticorps C20orf2, anticorps DIL-2, anticorps DIL2, anticorps FLS353, anticorps GD:C20orf1, anticorps HCA519, anticorps HCTP4, anticorps REPP86, anticorps p100, anticorps 2610005B21Rik, anticorps TPX2, anticorps dil-2, anticorps dil2, anticorps hctp4, anticorps repp86, anticorps tpx2, anticorps TPX2, microtubule nucleation factor, anticorps TPX2, microtubule-associated, anticorps TPX2, microtubule-associated, homolog (Xenopus laevis), anticorps TPX2, microtubule-associated S homeolog, anticorps TPX2, microtubule-associated L homeolog, anticorps TPX2, anticorps Tpx2, anticorps tpx2.S, anticorps tpx2.L

Sujet:

Description: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Gene: TPX2

Poids moléculaire: 85 kDa

ID gène: 22974

UniProt: Q9ULW0