EYA2 anticorps (Internal Region)

N° du produit ABIN6261629

Détail du produit anti-EYA2 anticorps

Antigène: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Épitope: Internal Region

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: EYA2 Antibody detects endogenous levels of total EYA2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EYA2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EYA2

Antigène: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Autre désignation: EYA2 (EYA2 Produits)

Synonymes: anticorps EYA2, anticorps zgc:92279, anticorps eab1, anticorps Eab1, anticorps EAB1, anticorps EYA transcriptional coactivator and phosphatase 2, anticorps EYA2, anticorps eya2, anticorps Eya2

Sujet:

Description: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1 (PubMed:12500905).

Gene: EYA2

Poids moléculaire: 59 kDa

ID gène: 2139

UniProt: O00167