GRIA2 anticorps (C-Term)

N° du produit ABIN6261987

Détail du produit anti-GRIA2 anticorps

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: GluR2 Antibody detects endogenous levels of total GluR2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human GluR2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur GRIA2

Antigène: GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

Autre désignation: GRIA2 (GRIA2 Produits)

Synonymes: anticorps GLUR2, anticorps GLURB, anticorps GluA2, anticorps GluR-K2, anticorps HBGR2, anticorps GluR-2, anticorps GluR-B, anticorps Glur-2, anticorps Glur2, anticorps GluR2, anticorps gluR-B, anticorps glur2a, anticorps gria2.1, anticorps zfGRIA2[a], anticorps glur2, anticorps glutamate ionotropic receptor AMPA type subunit 2, anticorps glutamate receptor, ionotropic, AMPA 2, anticorps glutamate receptor, ionotropic, AMPA2 (alpha 2), anticorps glutamate receptor, ionotropic, AMPA 2a, anticorps glutamate receptor, ionotropic, AMPA 2 S homeolog, anticorps GRIA2, anticorps Gria2, anticorps gria2a, anticorps gria2.S

Sujet:

Description: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).

Gene: GRIA2

Poids moléculaire: 99kDa

ID gène: 2891

UniProt: P42262

Pathways: Signalisation PI3K-Akt