HIPK1/2/3 anticorps

N° du produit ABIN6262241

Cet anticorps Lapin Polyclonal détecte spécifiquement dans ELISA et WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour HIPK1/2/3 anticorps (ABIN6262241)

Antigène: HIPK1/2/3

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Application: ELISA, Western Blotting (WB)

Détail du produit

Specificité: HIPK1/2/3 Antibody detects endogenous levels of HIPK1/2/3

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HIPK1/2/3

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détail du antigène

Antigène: HIPK1/2/3

Sujet:

Description: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Gene: HIPK1

Poids moléculaire: 130kDa

ID gène: 204851

UniProt: Q86Z02, Q9H2X6, Q9H422