CBX3 anticorps (Internal Region)

N° du produit ABIN6262358

Détail du produit anti-CBX3 anticorps

Antigène: CBX3 (Chromobox Homolog 3 (CBX3))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBX3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: HP1 gamma Antibody detects endogenous levels of total HP1 gamma.

Homologie: Pig,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HP1 gamma, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CBX3

Antigène: CBX3 (Chromobox Homolog 3 (CBX3))

Autre désignation: CBX3 (CBX3 Produits)

Synonymes: anticorps HECH, anticorps HP1-GAMMA, anticorps HP1Hs-gamma, anticorps Hp1-gamma, anticorps HP1g, anticorps M32, anticorps cbx3, anticorps cbx3a, anticorps xhp1g, anticorps wu:fb61b02, anticorps zgc:153397, anticorps chromobox 3, anticorps chromobox 3 L homeolog, anticorps chromobox protein homolog 3 pseudogene, anticorps chromobox homolog 3a (HP1 gamma homolog, Drosophila), anticorps CBX3, anticorps Cbx3, anticorps cbx3.L, anticorps LOC100355282, anticorps cbx3a

Sujet:

Description: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

Gene: CBX3

Poids moléculaire: 22kDa

ID gène: 11335

UniProt: Q13185