KPNA4 anticorps (C-Term)

N° du produit ABIN6262864

Détail du produit anti-KPNA4 anticorps

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: KPNA4 Antibody detects endogenous levels of total KPNA4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human KPNA4, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur KPNA4

Antigène: KPNA4 (Karyopherin (Importin) alpha 4 (KPNA4))

Autre désignation: KPNA4 (KPNA4 Produits)

Synonymes: anticorps IPOA3, anticorps QIP1, anticorps SRP3, anticorps 6, anticorps ATIMPALPHA3, anticorps IMPA-3, anticorps IMPORTIN ALPHA 3, anticorps IMPORTIN ALPHA ISOFORM 3, anticorps MODIFIER OF SNC1, anticorps T10M13.16, anticorps T10M13_16, anticorps LOC100224013, anticorps 1110058D08Rik, anticorps importin, anticorps ipoa3, anticorps qip1, anticorps srp3, anticorps impa3, anticorps wu:fa56d07, anticorps wu:fa66g10, anticorps wu:fe14c04, anticorps wu:fi04h11, anticorps wu:fi19b05, anticorps karyopherin subunit alpha 4, anticorps ARM repeat superfamily protein, anticorps importin alpha 3, anticorps karyopherin (importin) alpha 4, anticorps karyopherin alpha 4 (importin alpha 3) S homeolog, anticorps karyopherin alpha 4 (importin alpha 3), anticorps KPNA4, anticorps MOS6, anticorps LOC100533341, anticorps Kpna4, anticorps kpna4.S, anticorps kpna4

Sujet:

Description: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene: KPNA4

Poids moléculaire: 57kDa

ID gène: 3840

UniProt: O00629

Pathways: Protein targeting to Nucleus