MAGEA2B anticorps (C-Term)

N° du produit ABIN6263054

Détail du produit anti-MAGEA2B anticorps

Antigène: MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGEA2B est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: MAGEA2 Antibody detects endogenous levels of total MAGEA2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MAGEA2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MAGEA2B

Antigène: MAGEA2B (Melanoma Antigen Family A, 2B (MAGEA2B))

Autre désignation: MAGEA2, MAGEA2B (MAGEA2B Produits)

Synonymes: anticorps MAGE2, anticorps MAGEA2, anticorps MAGE family member A2B, anticorps MAGEA2B

Sujet:

Description: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Gene: MAGEA2, MAGEA2B

Poids moléculaire: 35 kDa

ID gène: 266740, 4101

UniProt: P43356