MAGEF1 anticorps (Internal Region)

N° du produit ABIN6263078

Cet anticorps Lapin Polyclonal détecte spécifiquement MAGEF1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour MAGEF1 anticorps (Internal Region) (ABIN6263078)

Antigène: MAGEF1 (Melanoma Antigen Family F, 1 (MAGEF1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGEF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MAGEF1 anticorps

Épitope: Internal Region

Specificité: MAGF1 Antibody detects endogenous levels of total MAGF1.

Homologie: Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MAGF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur MAGEF1

Antigène: MAGEF1 (Melanoma Antigen Family F, 1 (MAGEF1))

Autre désignation: MAGEF1

Sujet:

Description: Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034).

Gene: MAGEF1

Poids moléculaire: 35 kDa

ID gène: 64110

UniProt: Q9HAY2