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Necdin-Like 2 anticorps (Internal Region)

NDNL2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6263079
  • Antigène Voir toutes Necdin-Like 2 (NDNL2) Anticorps
    Necdin-Like 2 (NDNL2)
    Épitope
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 12
    • 11
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 11
    • 1
    Lapin
    Clonalité
    • 11
    • 1
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Necdin-Like 2 est non-conjugé
    Application
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    MAGG1 Antibody detects endogenous levels of total MAGG1.
    Homologie
    Bovine,Horse,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human MAGG1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product NDNL2 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Necdin-Like 2 (NDNL2)
    Autre désignation
    NSMCE3 (NDNL2 Produits)
    Synonymes
    anticorps mage, anticorps zgc:101850, anticorps NDNL2, anticorps HCA4, anticorps MAGEG1, anticorps MAGEL3, anticorps NSE3, anticorps NSMCE3, anticorps 5730494G16Rik, anticorps AI642138, anticorps BB044375, anticorps Mageg1, anticorps mage-g1, anticorps NSE3 homolog, SMC5-SMC6 complex component, anticorps necdin-like 2, anticorps Nsmce3, anticorps ndnl2, anticorps NDNL2, anticorps NSMCE3
    Sujet

    Description: Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).

    Gene: NSMCE3

    Poids moléculaire
    34 kDa
    ID gène
    56160
    UniProt
    Q96MG7
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