MLKL anticorps (Internal Region)

N° du produit ABIN6263279

Cet anticorps Lapin Polyclonal détecte spécifiquement MLKL dans WB, ELISA, IHC, IF et ICC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 1 publication.

Aperçu rapide pour MLKL anticorps (Internal Region) (ABIN6263279)

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLKL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-MLKL anticorps

Épitope: Internal Region

Specificité: MLKL Antibody detects endogenous levels of total MLKL.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human MLKL, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-MLKL (ABIN6263279)

Fang, Cao, Wang, Ye, Shen, Li, Hu, Gao: "Alterations in necroptosis during ALDH2‑mediated protection against high glucose‑induced H9c2 cardiac cell injury." dans: Molecular medicine reports, Vol. 18, Issue 3, pp. 2807-2815, (2018) (PubMed).

Détails sur MLKL

Antigène: MLKL (Mixed Lineage Kinase Domain-Like (MLKL))

Autre désignation: MLKL

Sujet:

Description: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Gene: MLKL

Poids moléculaire: 54kDa

ID gène: 197259

UniProt: Q8NB16