Nth Endonuclease III-Like 1 (NTHL1) (Internal Region) anticorps

N° du produit ABIN6263755

Cet anticorps anti-Nth Endonuclease III-Like 1 Polyclonal Lapin (ABIN6263755) détecte spécifiquement Nth Endonuclease III-Like 1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Singe.

Aperçu rapide pour Nth Endonuclease III-Like 1 (NTHL1) (Internal Region) anticorps (ABIN6263755)

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Détail du produit

Épitope: Internal Region

Fonction: NTHL1 Antibody

Specificité: NTHL1 Antibody detects endogenous levels of total NTHL1

Homologie: Pig,Zebrafish,Bovine,Horse,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NTHL1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détail du antigène

Antigène: Nth Endonuclease III-Like 1 (NTHL1)

Autre désignation: NTHL1

Sujet:

Description: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Gene: NTHL1

Poids moléculaire: 34 kDa

ID gène: 4913

UniProt: P78549