PRC1 anticorps (Internal Region)

N° du produit ABIN6264405

L’anticorps Lapin Polyclonal anti-PRC1 a été validé pour WB, ELISA, IHC, IF et ICC. Il convient pour détecter PRC1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PRC1 anticorps (Internal Region) (ABIN6264405)

Antigène: PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-PRC1 anticorps

Épitope: Internal Region

Specificité: PRC1 Antibody detects endogenous levels of total PRC1.

Homologie: Pig,Horse,Sheep,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PRC1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PRC1

Antigène: PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))

Autre désignation: PRC1

Sujet:

Description: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Gene: PRC1

Poids moléculaire: 72kDa

ID gène: 9055

UniProt: O43663