SGTA anticorps (C-Term)

N° du produit ABIN6265046

Détail du produit anti-SGTA anticorps

Antigène: SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SGTA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: SGTA Antibody detects endogenous levels of total SGTA.

Homologie: Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SGTA, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SGTA

Antigène: SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))

Autre désignation: SGTA (SGTA Produits)

Synonymes: anticorps sgta, anticorps SGTA, anticorps zgc:92462, anticorps SGT, anticorps alphaSGT, anticorps hSGT, anticorps 5330427H01Rik, anticorps AI194281, anticorps D10Ertd190e, anticorps Sgt, anticorps Stg, anticorps small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha, anticorps small glutamine rich tetratricopeptide repeat containing alpha, anticorps small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta, anticorps small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha L homeolog, anticorps sgta, anticorps SGTA, anticorps sgtb, anticorps sgta.L, anticorps Sgta

Sujet:

Description: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

Gene: SGTA

Poids moléculaire: 34-37 kDa

ID gène: 6449

UniProt: O43765