STAMBP anticorps (C-Term)

N° du produit ABIN6265307

Cet anticorps Lapin Polyclonal détecte spécifiquement STAMBP dans WB et ELISA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour STAMBP anticorps (C-Term) (ABIN6265307)

Antigène: STAMBP (STAM Binding Protein (STAMBP))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAMBP est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-STAMBP anticorps

Épitope: C-Term

Specificité: STAMBP Antibody detects endogenous levels of total STAMBP.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human STAMBP, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur STAMBP

Antigène: STAMBP (STAM Binding Protein (STAMBP))

Autre désignation: STAMBP

Sujet:

Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

Gene: STAMBP

Poids moléculaire: 50 kDa

ID gène: 10617

UniProt: O95630