ZFP36L1 anticorps (Internal Region)

N° du produit ABIN6265589

Détail du produit anti-ZFP36L1 anticorps

Antigène: ZFP36L1 (ZFP36 Ring Finger Protein-Like 1 (ZFP36L1))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFP36L1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: TIS11B Antibody detects endogenous levels of total TIS11B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TIS11B, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ZFP36L1

Antigène: ZFP36L1 (ZFP36 Ring Finger Protein-Like 1 (ZFP36L1))

Autre désignation: ZFP36L1 (ZFP36L1 Produits)

Synonymes: anticorps ZFP36L1, anticorps berg36, anticorps brf1, anticorps c3h-2, anticorps cmg1, anticorps erf-1, anticorps erf1, anticorps rnf162b, anticorps tis11b, anticorps BRF1, anticorps Berg36, anticorps ERF-1, anticorps ERF1, anticorps RNF162B, anticorps TIS11B, anticorps cMG1, anticorps Brf1, anticorps TIS11b, anticorps AW742437, anticorps AW743212, anticorps D530020L18Rik, anticorps cb198, anticorps cb480, anticorps fk89d11, anticorps id:ibd1247, anticorps sb:cb198, anticorps sb:cb480, anticorps wu:fb80h11, anticorps wu:fb92f07, anticorps wu:fk89d11, anticorps zfp36l1, anticorps zfp36l2, anticorps zgc:153979, anticorps fc06f10, anticorps wu:fc06f10, anticorps zfp36l1l, anticorps zgc:77882, anticorps ZFP36 ring finger protein-like 1 S homeolog, anticorps ZFP36 ring finger protein like 1, anticorps zinc finger protein 36, C3H type-like 1, anticorps zinc finger protein 36, C3H type-like 1a, anticorps BRF1, RNA polymerase III transcription initiation factor subunit, anticorps transcription factor IIIB 90 kDa subunit, anticorps zinc finger protein 36, C3H type-like 1b, anticorps zfp36l1.S, anticorps ZFP36L1, anticorps Zfp36l1, anticorps zfp36l1a, anticorps BRF1, anticorps LOC100350146, anticorps zfp36l1b

Sujet:

Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing, modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).

Gene: ZFP36L1

Poids moléculaire: 36kDa

ID gène: 677

UniProt: Q07352