TRIM14 anticorps (C-Term)

N° du produit ABIN6265727

Détail du produit anti-TRIM14 anticorps

Antigène: TRIM14 (Tripartite Motif Containing 14 (TRIM14))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM14 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: TRIM14 Antibody detects endogenous levels of total TRIM14.

Homologie: Pig,Bovine,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TRIM14, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TRIM14

Antigène: TRIM14 (Tripartite Motif Containing 14 (TRIM14))

Autre désignation: TRIM14 (TRIM14 Produits)

Synonymes: anticorps TRIM14, anticorps 5830400N10Rik, anticorps pub, anticorps tripartite motif containing 14, anticorps tripartite motif-containing 14, anticorps TRIM14, anticorps Trim14

Sujet:

Description: Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593).

Gene: TRIM14

Poids moléculaire: 50 kDa

ID gène: 9830

UniProt: Q14142