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YME1L1 anticorps (C-Term)

YME1L1 Reactivité: Humain, Souris, Rat WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6266079
  • Antigène Voir toutes YME1L1 Anticorps
    YME1L1 (YME1-Like 1 (YME1L1))
    Épitope
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    C-Term
    Reactivité
    • 22
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 21
    • 1
    Lapin
    Clonalité
    • 21
    • 1
    Polyclonal
    Conjugué
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    Cet anticorp YME1L1 est non-conjugé
    Application
    • 21
    • 19
    • 18
    • 13
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    YME1L1 Antibody detects endogenous levels of total YME1L1.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human YME1L1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product YME1L1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    YME1L1 (YME1-Like 1 (YME1L1))
    Autre désignation
    YME1L1 (YME1L1 Produits)
    Synonymes
    anticorps FtsH1, anticorps Ftsh, anticorps FTSH, anticorps MEG4, anticorps PAMP, anticorps YME1L, anticorps YME1-like 1 (S. cerevisiae), anticorps YME1-like 1 ATPase, anticorps YME1 like 1 ATPase, anticorps Yme1l1, anticorps YME1L1
    Sujet

    Description: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).

    Gene: YME1L1

    Poids moléculaire
    86 kDa
    ID gène
    10730
    UniProt
    Q96TA2
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