ZEB1 anticorps (Internal Region)

N° du produit ABIN6266096

Détail du produit anti-ZEB1 anticorps

Antigène: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZEB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: ZEB1 Antibody detects endogenous levels of total ZEB1.

Homologie: Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ZEB1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-ZEB1 (ABIN6266096)

Shao, Zhang, Ma, Lu, Meng, Li, Wang, Chen, Zhang, Han, Liu, Ma: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." dans: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).

Li, Shen, Wang, Li, Wang, Jiang, Zhou, Feng: "EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells." dans: Scientific reports, Vol. 5, pp. 11009, (2016) (PubMed).

Li, Zhang, Sun, Sun, Shi, Liu, Liu: "MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells." dans: International journal of oncology, Vol. 47, Issue 4, pp. 1379-92, (2016) (PubMed).

Détails sur ZEB1

Antigène: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Autre désignation: ZEB1 (ZEB1 Produits)

Synonymes: anticorps ZFH/[d]EF1, anticorps kheper, anticorps zeb1, anticorps zfhx1, anticorps bzp, anticorps zeb, anticorps tcf8, anticorps areb6, anticorps nil2a, anticorps zfhep, anticorps nil-2a, anticorps zfhx1a, anticorps nil-2-a, anticorps MGC97552, anticorps TCF8, anticorps AREB6, anticorps BZP, anticorps DELTAEF1, anticorps FECD6, anticorps NIL2A, anticorps PPCD3, anticorps ZFHEP, anticorps ZFHX1A, anticorps 3110032K11Rik, anticorps MEB1, anticorps Nil2, anticorps TCF-8, anticorps Tcf18, anticorps Tcf8, anticorps Tw, anticorps ZEB, anticorps Zfhep, anticorps Zfhx1a, anticorps Zfx1a, anticorps Zfx1ha, anticorps [delta]EF1, anticorps deltaEF1, anticorps deltaef1, anticorps fecd6, anticorps zinc finger E-box binding homeobox 1b, anticorps zinc finger E-box binding homeobox 1, anticorps zinc finger E-box binding homeobox 1 S homeolog, anticorps zeb1b, anticorps zeb1, anticorps ZEB1, anticorps Zeb1, anticorps zeb1.S

Sujet:

Description: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Gene: ZEB1

Poids moléculaire: 124kDa

ID gène: 6935

UniProt: P37275

Pathways: Regulation of Muscle Cell Differentiation