TRIM63 anticorps (N-Term)

N° du produit ABIN6266286

Détail du produit anti-TRIM63 anticorps

Antigène: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM63 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: TRIM63 Antibody detects endogenous levels of total TRIM63.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TRIM63, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:100, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur TRIM63

Antigène: TRIM63 (Tripartite Motif Containing 63 (TRIM63))

Autre désignation: TRIM63 (TRIM63 Produits)

Synonymes: anticorps IRF, anticorps MURF1, anticorps MURF2, anticorps RNF28, anticorps SMRZ, anticorps Murf, anticorps Murf1, anticorps Rnf28, anticorps MuRF1, anticorps RF1, anticorps rnf30, anticorps MGC80210, anticorps TRIM63, anticorps MuRF, anticorps fc50c07, anticorps trim63, anticorps wu:fc50c07, anticorps zgc:86757, anticorps tripartite motif containing 63, anticorps tripartite motif-containing 63, anticorps tripartite motif containing 63 S homeolog, anticorps tripartite motif containing 63a, anticorps TRIM63, anticorps Trim63, anticorps trim63.S, anticorps trim63a

Sujet:

Description: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Gene: TRIM63

Poids moléculaire: 40kDa

ID gène: 84676

UniProt: Q969Q1