ESR2 anticorps (C-Term)

N° du produit ABIN6294672

Cet anticorps anti-ESR2 est un anticorps Souris Monoclonal détectant ESR2 dans WB, IHC, IF et FACS. Adapté pour Humain, Souris, Rat, Mouton, Porc, Cheval et Singe.

Aperçu rapide pour ESR2 anticorps (C-Term) (ABIN6294672)

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivité: Humain, Souris, Rat, Mouton, Porc, Cheval, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-ESR2 anticorps

Épitope: C-Term

Fonction: Mouse anti-Human/Monkey/Mouse/Rat/Pig/Horse/Sheep Estrogen Receptor beta Antibody [Sodium Azide Free]

Specificité: Predominantly nuclear

Purification: The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.

Immunogène: The C-terminus fragment of recombinant human Estrogen Receptor beta protein was used as the immunogen for this antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/10e6 cells
IF: 1-2 μg/mL
WB: 0.5-1 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 minutes at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: Estrogen receptor beta

Sujet:

Target Description: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including alpha and beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER alpha and beta are differentially activated by various ligands. Ligand interaction triggers a cascade of events, including dissociation from heat shock proteins, recepter dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Gene Symbol: ESR2///ESTRB///NR3A2

ID gène: 2100

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling