Desmocollin 2 anticorps (Extracellular Domain)

N° du produit ABIN6295454

L’anticorps Souris Monoclonal anti-Desmocollin 2 a été validé pour WB, IHC, IF et FACS. Il convient pour détecter Desmocollin 2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Desmocollin 2 anticorps (Extracellular Domain) (ABIN6295454)

Antigène: Desmocollin 2 (DSC2)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Desmocollin 2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-Desmocollin 2 anticorps

Épitope: Extracellular Domain

Fonction: Mouse anti-Human/Mouse/Rat Desmocollin 2/3 Antibody [Sodium Azide Free]

Specificité: Cell surface

Purification: A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.

Immunogène: A recombinant protein corresponding to the extracellular domain of human Desmocollin 2 was used as the immunogen for the Desmocollin 2/3 antibody.

Information d'application

Indications d'application: WB: 0.5-1 μg/mL
FACS: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur Desmocollin 2

Antigène: Desmocollin 2 (DSC2)

Autre désignation: Desmocollin-2

Sujet:

Target Description: Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of Desmocollin-2 varies in the basal and suprabasal layers. And Desmocollin-3 is expressed more evenly throughout the suprabasal layers.

Gene Symbol: DSC2///CDHF2///DSC3

ID gène: 1824

UniProt: Q02487