TNFSF15 anticorps

N° du produit ABIN6295967

L’anticorps anti-TNFSF15 Monoclonal Souris est utilisé pour la détection de TNFSF15 dans des échantillons de Humain. Il a été validé pour WB, IHC, IF et FACS.

Aperçu rapide pour TNFSF15 anticorps (ABIN6295967)

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF15 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-TNFSF15 anticorps

Fonction: Mouse anti-Human VEGI / TL1A Antibody [Sodium Azide Free]

Specificité: Cytoplasmic, cell surface, secreted

Purification: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Immunogène: A full length human recombinant protein was used as the immunogen for this TL1A antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TNFSF15

Antigène: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Autre désignation: Tumor necrosis factor ligand superfamily member 15

Sujet:

Target Description: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

Gene Symbol: TNFSF15///TL1///VEGI

ID gène: 9966

UniProt: O95150

Pathways: Positive Regulation of Endopeptidase Activity, Autophagy