MAML3 anticorps

N° du produit ABIN6295979

L’anticorps Souris Monoclonal anti-MAML3 a été validé pour FACS, IF et IHC. Il convient pour détecter MAML3 dans des échantillons de Humain.

Aperçu rapide pour MAML3 anticorps (ABIN6295979)

Antigène: MAML3 (Mastermind-Like 3 (MAML3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAML3 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-MAML3 anticorps

Fonction: Mouse anti-Human MAML3 Antibody [Sodium Azide Free]

Specificité: Cytoplasmic

Purification: A human full length recombinant protein was used as the immunogen for this MAML3 antibody.

Immunogène: A human full length recombinant protein was used as the immunogen for this MAML3 antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur MAML3

Antigène: MAML3 (Mastermind-Like 3 (MAML3))

Autre désignation: Mastermind-like protein 3

Sujet:

Target Description: Mastermind-like 3 is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch 1-4 proteins. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jκ, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, its upregulation is thought to be involved in oncogenesis.

Gene Symbol: MAML3///KIAA1816

ID gène: 55534

UniProt: Q96JK9