RNMT anticorps

N° du produit ABIN6296035

Cet anticorps Souris Monoclonal détecte spécifiquement RNMT dans IHC. Il présente une réactivité envers Humain, Rat, Boeuf (Vache) et Chien.

Aperçu rapide pour RNMT anticorps (ABIN6296035)

Antigène: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Reactivité: Humain, Rat, Boeuf (Vache), Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RNMT est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-RNMT anticorps

Fonction: Mouse anti-Human/Cow/Dog/Rat TAG-72 Antibody Cocktail [IHC only]

Specificité: Cytoplasmic and cell surface

Purification: A membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and purified TAG-72 protein (CC49) were used as the immunogens for this TAG-72 antibody cocktail.

Immunogène: A membrane-enriched fraction of a human breast carcinoma liver metastasis (B72.3) and purified TAG-72 protein (CC49) were used as the immunogens for this TAG-72 antibody cocktail.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur RNMT

Antigène: RNMT (RNA Guanine-7 Methyltransferase (RNMT))

Autre désignation: mRNA cap guanine-N7 methyltransferase  

Sujet:

Target Description: Recognizes an oncofetal antigen of 220 kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This mAb defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80 % sensitivity and 93 % specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution. This antibody may be useful in the differentiation of non-small cell carcinomas from small cell carcinomas of the lung. The combined use of anti-TAG-72 and anti-GCDFP-15 is valuable in the diagnosis of apocrine carcinoma.

Gene Symbol: tag-72  C25A1.3

ID gène: 182875

UniProt: Q9XVS1