MUC1 anticorps

N° du produit ABIN6296211

Cet anticorps anti-MUC1 Monoclonal Souris (ABIN6296211) détecte spécifiquement MUC1 dans IHC, ELISA, FACS et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour MUC1 anticorps (ABIN6296211)

Antigène: MUC1 (Mucin 1 (MUC1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-MUC1 anticorps

Fonction: Mouse anti-Human/Mouse MUC-1 Antibody [Sodium Azide Free]

Specificité: Cytoplasmic and cell surface

Purification: Breast cancer cell line ZR75-1 was used as the immunogen for the anti-MUC-1 antibody.

Immunogène: Breast cancer cell line ZR75-1 was used as the immunogen for the anti-MUC-1 antibody.

Information d'application

Indications d'application: ELISA: use Ab at 2-5 μg/mL, order BSA-free format
Flow Cytometry: 0.25-0.5 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur MUC1

Antigène: MUC1 (Mucin 1 (MUC1))

Autre désignation: Mucin-1 ]

Sujet:

Target Description: This mAb reacts with MUC1/Mucin-1/Epithelial Marker Antigen/EMA. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90 % breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

Gene Symbol: MUC1///PUM

ID gène: 4582

UniProt: P15941

Pathways: Negative Regulation of intrinsic apoptotic Signaling