Transferrin anticorps

N° du produit ABIN6296728

Cet anticorps Souris Monoclonal détecte spécifiquement Transferrin dans IHC et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Transferrin anticorps (ABIN6296728)

Antigène: Transferrin (TF)

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Transferrin anticorps

Fonction: Mouse anti-Human/Mouse/Rat CD176 Antibody [Sodium Azide Free]

Specificité: Cell surface

Purification: Neuraminidase-treated human red blood cells were used as the immunogen for the CD176 antibody.

Immunogène: Neuraminidase-treated human red blood cells were used as the immunogen for the CD176 antibody.

Information d'application

Indications d'application: Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 3-5 μg/mL for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur Transferrin

Antigène: Transferrin (TF)

Autre désignation: CD176

Sujet:

Target Description: Recognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in normal adult tissues but increasing to fetal levels of expression in hyperplasia or malignancy. It is considered as a pan-carcinoma marker. During metastasis, the ability of malignant cells to form multicellular aggregates via homotypic or heterotypic aggregation and their adhesion to the endothelium are critical. The tumor-associated carbohydrate Thomsen-Friedenreich antigen (Gal-GalNAc) is involved in tumor cell adhesion and tissue invasion. It also causes an immune response, and overexpression of the antigen causes cancer cells to be more sensitive to natural killer cell lysis. The Thomsen-Friedenreich antigen is suppressed in normal healthy cells and represents one of the few chemically well-defined antigens associated with tumor malignancy. The presence of the Thomsen-Friedenreich antigen on the surface of cancer cells may result from a divergence from the normal pathway for O-linked glycosylation in these cells, most likely caused by inappropriate localization of the enzymes involved in synthesis of the disaccharide.

Pathways: Transition Metal Ion Homeostasis