IGHA1 anticorps

N° du produit ABIN6296837

L’anticorps anti-IGHA1 Monoclonal Souris est utilisé pour la détection de IGHA1 dans des échantillons de Humain. Il a été validé pour IHC, FACS et IF.

Aperçu rapide pour IGHA1 anticorps (ABIN6296837)

Antigène: IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGHA1 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-IGHA1 anticorps

Fonction: Mouse anti-Human IgA Antibody [Sodium Azide Free]

Specificité: Cytoplasm, cell surface and secreted

Purification: Purified human alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Immunogène: Purified human alpha heavy chain was used as the immunogen for the Anti-IgA antibody.

Information d'application

Indications d'application: Flow Cytometry: 1-2 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL 30 min RT
Immunohistochemistry (FFPE): 0.5-1 μg/mL 30 min RT (1)

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur IGHA1

Antigène: IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

Autre désignation: Immunoglobulin heavy constant alpha 1

Sujet:

Target Description: This mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Gene Symbol: IGHA1///IGHA2

UniProt: P01876, P01877