Intestinal Alkaline Phosphatase anticorps

N° du produit ABIN6297135

Cet anticorps anti-Intestinal Alkaline Phosphatase est un anticorps Souris Monoclonal détectant Intestinal Alkaline Phosphatase dans IHC. Adapté pour Humain.

Aperçu rapide pour Intestinal Alkaline Phosphatase anticorps (ABIN6297135)

Antigène: Intestinal Alkaline Phosphatase (ALPI)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Intestinal Alkaline Phosphatase est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-Intestinal Alkaline Phosphatase anticorps

Fonction: Mouse anti-Human Alkaline Phosphatase Antibody (tissue-nonspecific) [IHC only]

Specificité: Cell surface, cytoplasmic

Purification: Recombinant human ALPL protein was used as the immunogen for the tissue-nonspecific Alkaline Phosphatase antibody.

Immunogène: Recombinant human ALPL protein was used as the immunogen for the tissue-nonspecific Alkaline Phosphatase antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur Intestinal Alkaline Phosphatase

Antigène: Intestinal Alkaline Phosphatase (ALPI)

Autre désignation: Intestinal-type alkaline phosphatase

Sujet:

Target Description: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Gene Symbol: ALPI

ID gène: 248

UniProt: P09923