TYMS anticorps

N° du produit ABIN6297576

Cet anticorps anti-TYMS est un anticorps Souris Monoclonal détectant TYMS dans IHC. Adapté pour Humain.

Aperçu rapide pour TYMS anticorps (ABIN6297576)

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TYMS est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-TYMS anticorps

Fonction: Mouse anti-Human Thymidylate Synthase Antibody [IHC only]

Specificité: Cytoplasmic

Purification: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Immunogène: Recombinant human Thymidylate synthase was used as the immunogen for this antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TYMS

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Autre désignation: Thymidylate synthase

Sujet:

Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Gene Symbol: TYMS///TS///OK///SW-cl.29

ID gène: 7298

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases