TSH receptor anticorps

N° du produit ABIN6297581

Détail du produit anti-TSH receptor anticorps

Antigène: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TSH receptor est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)

Fonction: Mouse anti-Human Thyroid Stimulating Hormone Receptor / TSHR Antibody (alpha chain) [Sodium Azide Free]

Specificité: Cytoplasmic, cell surface

Purification: Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.

Immunogène: Recombinant human TSH Receptor alpha chain protein was used as the immunogen for this TSHR antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur TSH receptor

Antigène: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Autre désignation: Thyrotropin receptor (TSHR Produits)

Synonymes: anticorps CHNG1, anticorps LGR3, anticorps hTSHR-I, anticorps AI481368, anticorps hypothroid, anticorps hyt, anticorps pet, anticorps TSHRA, anticorps TSH-R, anticorps thyroid stimulating hormone receptor, anticorps tshr, anticorps TSHR, anticorps Tshr

Sujet:

Target Description: Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Gene Symbol: TSHR///LGR3

ID gène: 7253

UniProt: P16473

Pathways: Thyroid Hormone Synthesis