IGHM anticorps

N° du produit ABIN6297767

L’anticorps Souris Monoclonal anti-IGHM a été validé pour IHC. Il convient pour détecter IGHM dans des échantillons de Humain.

Aperçu rapide pour IGHM anticorps (ABIN6297767)

Antigène: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IGHM est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-IGHM anticorps

Fonction: Mouse anti-Human IgM Antibody [IHC only]

Specificité: Cytoplasm, cell surface and secreted

Purification: The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.

Immunogène: The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.

Information d'application

Indications d'application: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Stockage

Buffer: Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur IGHM

Antigène: IGHM (Immunoglobulin Heavy Constant mu (IGHM))

Autre désignation: Immunoglobulin heavy constant mu

Sujet:

Target Description: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.

Gene Symbol: IGHM

ID gène: 3507

UniProt: P01871