IGHM anticorps
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- Antigène Tous les produits IGHM
- IGHM (Immunoglobulin Heavy Constant mu (IGHM))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp IGHM est non-conjugé
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Application
- Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
- Fonction
- Mouse anti-Human IgM Antibody [Sodium Azide Free]
- Specificité
- Cytoplasm, cell surface and secreted
- Purification
- The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.
- Immunogène
- The Mu heavy chain of human Ig was used as the immunogen for the Anti-IgM antibody.
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- Indications d'application
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) - Restrictions
- For Research Use only
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- Buffer
- In 1X PBS, BSA free, sodium azide free
- Agent conservateur
- Azide free
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Antigène
- IGHM (Immunoglobulin Heavy Constant mu (IGHM))
- Autre désignation
- Immunoglobulin heavy constant mu (IGHM Produits)
- Synonymes
- anticorps AI326478, anticorps Igh-6, anticorps Igh-M, anticorps Igh6, anticorps Igm, anticorps muH, anticorps ighm1, anticorps wu:fj14a08, anticorps zgc:101769, anticorps AGM1, anticorps MU, anticorps VH, anticorps immunoglobulin heavy constant mu, anticorps Ighm, anticorps ighm, anticorps IGHM
- Sujet
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Target Description: Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This mAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
Gene Symbol: IGHM
- ID gène
- 3507
- UniProt
- P01871
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