KNG1 anticorps (Biotin)

N° du produit ABIN6297826

Détail du produit anti-KNG1 anticorps (Biotin)

Antigène: KNG1 (Kininogen 1 (KNG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KNG1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA

Fonction: Rabbit anti-Human Bradykinin [+Biotin] Antibody,

Immunogène: This antibody was produced from antiserum of rabbits immunized with a polypeptide immunogen. The IgG fraction was purified by Protein G/A affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: ELISA (recommended work dilution= 1:16,000), Western Blotting (recommended work dilution= 1:1,000-5,002),

Restrictions: For Research Use only

Stockage

Reconstitution: Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/mL.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: -20°C

Détails sur KNG1

Antigène: KNG1 (Kininogen 1 (KNG1))

Autre désignation: Kininogen-1 , Kininogen-1 light chain, Low molecular weight growth-promoting factor] (KNG1 Produits)

Synonymes: anticorps BDK, anticorps BK, anticorps KNG, anticorps Kng, anticorps KNG2, anticorps fb64g01, anticorps wu:fb64g01, anticorps zgc:103569, anticorps kininogen, anticorps bdk, anticorps kng, anticorps KNG1, anticorps IHRP, anticorps KINKG, anticorps KINKH, anticorps Kng1, anticorps Kngk, anticorps kininogen 1, anticorps kininogen 1 L homeolog, anticorps inter-alpha-trypsin inhibitor heavy chain family member 4, anticorps kininogen 2-like 1, anticorps KNG1, anticorps Kng1, anticorps kng1, anticorps kng1.L, anticorps ITIH4, anticorps Kng2l1

Sujet:

Target Description: Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.Bradykinin also causes natriuresis, contributing to the drop in blood pressure.Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor drugs. It is thought that bradykinin is converted to inactive metabolites by ACE, therefore inhibition of this enzyme leads to increased levels of bradykinin, which causes a dry cough via bronchoconstriction. This refractory cough is a common cause for stopping ACE inhibitor therapy, in which case angiotensin II receptor antagonists (ARBs) are the next line of treatment.Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as hereditary angio-neurotic edema.

Gene Symbol: KNG1///BDK///KNG

ID gène: 3827

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process