MCM10 anticorps (Middle Region)

N° du produit ABIN634085

L’anticorps anti-MCM10 Polyclonal Lapin est utilisé pour la détection de MCM10 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MCM10 anticorps (Middle Region) (ABIN634085)

Antigène: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM10 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MCM10 anticorps

Épitope: Middle Region

Specificité: MCM10 antibody was raised against the middle region of MCM10

Purification: Affinity purified

Immunogène: MCM10 antibody was raised using the middle region of MCM10 corresponding to a region with amino acids PKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERV

Information d'application

Indications d'application: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

MCM10 Blocking Peptide, (ABIN5614695), is also available for use as a blocking control in assays to test for specificity of this MCM10 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of MCM10 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Détails sur MCM10

Antigène: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Autre désignation: MCM10

Sujet: This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.

Poids moléculaire: 98 kDa (MW of target protein)

Pathways: Mitotic G1-G1/S Phases, DNA Replication