Natural Killer Cells anticorps

N° du produit ABIN642458

L’anticorps anti-Natural Killer Cells Monoclonal Souris est utilisé pour la détection de Natural Killer Cells dans des échantillons de Souris. Il a été validé pour Func, FACS et IP.

Aperçu rapide pour Natural Killer Cells anticorps (ABIN642458)

Antigène: Natural Killer Cells

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Application: Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)

Détail du produit

Fonction: Mouse Anti-Mouse NK-1.1 Ag.

Specificité: DS-MB-02011 recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family.In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that this antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by DS-MB-2011 appears to be even more complex, as only some CD161b positive strains are labeled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. DS-MB-02011 is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. The antibody has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.

Immunogène: Spleen and bone marrow cells from CE mice

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry, Functional Assays, Immunoprecipitation

Restrictions: For Research Use only

Stockage

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline, pH 7.4

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: Natural Killer Cells