HAS2 anticorps (AA 138-166)

N° du produit ABIN651874

Cet anticorps Lapin Polyclonal détecte spécifiquement HAS2 dans WB, FACS et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 2+ publications.

Aperçu rapide pour HAS2 anticorps (AA 138-166) (ABIN651874)

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAS2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB22492

Détail du produit anti-HAS2 anticorps

Épitope: AA 138-166

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This HAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids of human HAS2.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-HAS2 (ABIN651874)

Lien, Lee, Jeng, Lin, Lu, Yao: "Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance." dans: Histopathology, Vol. 65, Issue 3, pp. 328-39, (2015) (PubMed).

Kobayashi, Banno, Shimizu, Ueki, Tsuji, Masuda, Kisu, Nomura, Tominaga, Nagano, Saya, Aoki: "Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta." dans: Placenta, Vol. 34, Issue 2, pp. 110-8, (2013) (PubMed).

Détails sur HAS2

Antigène: HAS2 (Hyaluronan Synthase 2 (HAS2))

Autre désignation: HAS2

Sujet: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Poids moléculaire: 63566

ID gène: 3037

NCBI Accession: NP_005319

UniProt: Q92819

Pathways: Glycosaminoglycan Metabolic Process