BRSK1 anticorps (C-Term)

N° du produit ABIN652432

Cet anticorps Lapin Polyclonal détecte spécifiquement BRSK1 dans WB et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour BRSK1 anticorps (C-Term) (ABIN652432)

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRSK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB5415

Détail du produit anti-BRSK1 anticorps

Épitope: AA 654-684, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BRSK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-684 amino acids from the C-terminal region of human BRSK1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur BRSK1

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Autre désignation: BRSK1

Sujet: BRSK1 may be involved as a checkpoint kinase in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. This protein phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. BRSK1 is partitioned between cytoplasmic and nuclear locations in the absence of DNA damage, but translocates to the nucleus in response to Uv- or MMS-induced DNA damage. BRSK1 shares significant homology with the fission yeast Cdr2, a mitosis-regulatory kinase, and Caenorhabditis elegans SAD1, a neuronal cell polarity regulator. The BRSK1 transcript is expressed ubiquitously with the highest levels of expression in brain and testis.

Poids moléculaire: 85087

ID gène: 84446

NCBI Accession: NP_115806

UniProt: Q8TDC3