LMX1B anticorps (AA 175-202)

N° du produit ABIN652882

Cet anticorps Lapin Polyclonal détecte spécifiquement LMX1B dans WB et IHC (p). Il présente une réactivité envers Humain et Souris et a été mentionné dans 2+ publications.

Aperçu rapide pour LMX1B anticorps (AA 175-202) (ABIN652882)

Antigène: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LMX1B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21468

Détail du produit anti-LMX1B anticorps

Épitope: AA 175-202

Homologie: C, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-LMX1B (ABIN652882)

Doucet-Beaupré, Gilbert, Profes, Chabrat, Pacelli, Giguère, Rioux, Charest, Deng, Laguna, Ericson, Perlmann, Ang, Cicchetti, Parent, Trudeau, Lévesque: "Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 30, pp. E4387-96, (2018) (PubMed).

Laguna, Schintu, Nobre, Alvarsson, Volakakis, Jacobsen, Gómez-Galán, Sopova, Joodmardi, Yoshitake, Deng, Kehr, Ericson, Svenningsson, Shupliakov, Perlmann: "Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease." dans: Nature neuroscience, Vol. 18, Issue 6, pp. 826-35, (2015) (PubMed).

Détails sur LMX1B

Antigène: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Autre désignation: LMX1B

Sujet: LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.

Poids moléculaire: 44917

ID gène: 4010

NCBI Accession: NP_001167618, NP_002307

UniProt: O60663

Pathways: Dopaminergic Neurogenesis