GSTa2 anticorps (N-Term)

N° du produit ABIN653362

Détail du produit anti-GSTa2 anticorps

Antigène: GSTa2 (Glutathione S-Transferase alpha 2 (GSTa2))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSTa2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This GSTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GSTA2.

Clone: RB24006

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-GSTa2 (ABIN653362)

Huang, Guo, Li, Zhang: "Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes." dans: Scientific reports, Vol. 7, pp. 40716, (2018) (PubMed).

Li, Yuan, Li, Liu, Hua, Lu, Zhang: "Direct differentiation of homogeneous human adipose stem cells into functional hepatocytes by mimicking liver embryogenesis." dans: Journal of cellular physiology, Vol. 229, Issue 6, pp. 801-12, (2014) (PubMed).

Détails sur GSTa2

Antigène: GSTa2 (Glutathione S-Transferase alpha 2 (GSTa2))

Autre désignation: GSTA2 (GSTa2 Produits)

Synonymes: anticorps GSTA1, anticorps GST2, anticorps GSTA2-2, anticorps GTA2, anticorps GTH2, anticorps Gsta1, anticorps Gst2-2, anticorps Gstc-2, anticorps Gstc2, anticorps glutathione S-transferase alpha 2, anticorps glutathione S-transferase, anticorps glutathione S-transferase, alpha 2 (Yc2), anticorps GSTA2, anticorps Gsta2

Sujet: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Poids moléculaire: 25664

ID gène: 2939

NCBI Accession: NP_000837

UniProt: P09210