DHCR7 anticorps (C-Term)

N° du produit ABIN655399

Cet anticorps Lapin Polyclonal détecte spécifiquement DHCR7 dans WB, IF et IHC (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour DHCR7 anticorps (C-Term) (ABIN655399)

Antigène: DHCR7 (7-Dehydrocholesterol Reductase (DHCR7))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DHCR7 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17942

Détail du produit anti-DHCR7 anticorps

Épitope: AA 437-463, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DHCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-463 amino acids from the C-terminal region of human DHCR7.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:25. IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur DHCR7

Antigène: DHCR7 (7-Dehydrocholesterol Reductase (DHCR7))

Autre désignation: DHCR7

Sujet: This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Poids moléculaire: 54489

ID gène: 1717

NCBI Accession: NP_001157289, NP_001351

UniProt: Q9UBM7