TRIM72 anticorps (C-Term)

N° du produit ABIN655919

L’anticorps Lapin Polyclonal anti-TRIM72 a été validé pour WB et IHC (p). Il convient pour détecter TRIM72 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour TRIM72 anticorps (C-Term) (ABIN655919)

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM72 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB29696

Détail du produit anti-TRIM72 anticorps

Épitope: AA 299-327, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur TRIM72

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Autre désignation: TRIM72

Sujet: TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Poids moléculaire: 52731

ID gène: 493829

NCBI Accession: NP_001008275

UniProt: Q6ZMU5