TGIF1 anticorps (AA 145-174)

N° du produit ABIN656000

L’anticorps anti-TGIF1 Polyclonal Lapin est utilisé pour la détection de TGIF1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour TGIF1 anticorps (AA 145-174) (ABIN656000)

Antigène: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGIF1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB14111

Détail du produit anti-TGIF1 anticorps

Épitope: AA 145-174

Homologie: C

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human TGIF1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur TGIF1

Antigène: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Autre désignation: TGIF1

Sujet: The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.

Poids moléculaire: 43013

ID gène: 7050

NCBI Accession: NP_001265611, NP_001265613, NP_001265615, NP_003235, NP_733796, NP_775299, NP_775300, NP_775301, NP_775302, NP_775303, NP_777480

UniProt: Q15583

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation