ELANE anticorps (AA 28-58)

N° du produit ABIN656021

L’anticorps Lapin Polyclonal anti-ELANE a été validé pour WB. Il convient pour détecter ELANE dans des échantillons de Humain.

Aperçu rapide pour ELANE anticorps (AA 28-58) (ABIN656021)

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELANE est non-conjugé

Application: Western Blotting (WB)

Clone: RB18822

Détail du produit anti-ELANE anticorps

Épitope: AA 28-58

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Neutrophil elastase antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-58amino acids of human Neutrophil elastase.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur ELANE

Antigène: ELANE (Elastase, Neutrophil Expressed (ELANE))

Autre désignation: Neutrophil elastase

Sujet: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Poids moléculaire: 28518

ID gène: 1991

NCBI Accession: NP_001963

UniProt: P08246