HCAR2 anticorps (AA 200-228)

N° du produit ABIN656596

Détail du produit anti-HCAR2 anticorps

Antigène: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Épitope: AA 200-228

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HCAR2 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NIACR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids of human NIACR1.

Clone: RB31358

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: NIACR1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur HCAR2

Antigène: HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))

Autre désignation: NIACR1 (HCAR2 Produits)

Synonymes: anticorps GPR109A, anticorps HCA2, anticorps HM74a, anticorps HM74b, anticorps NIACR1, anticorps PUMAG, anticorps Puma-g, anticorps Gpr109a, anticorps Gpr109b, anticorps HM74, anticorps Hcar2, anticorps PUMA-G, anticorps Pumag, anticorps mHM74b, anticorps HCAR2, anticorps HCAR3, anticorps hydroxycarboxylic acid receptor 2, anticorps HCAR2, anticorps Hcar2, anticorps LOC527744

Sujet: NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

Poids moléculaire: 41850

ID gène: 338442

NCBI Accession: NP_808219

UniProt: Q8TDS4