MECP2 anticorps

N° du produit ABIN6566655

Cet anticorps Lapin Polyclonal détecte spécifiquement MECP2 dans WB et IHC. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour MECP2 anticorps (ABIN6566655)

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MECP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MECP2 anticorps

Purification: Affinity purification

Immunogène: Recombinant protein of human MECP2

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:1000 IHC 1:50 - 1:100

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur MECP2

Antigène: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Autre désignation: MECP2

Sujet:

Synonyms: AUTSX 3,AUTSX3,DKFZp686A24160,Mbd 5,Mbd5,MECP 2,MeCP 2 protein,MeCP-2 protein,Mecp2,MECP2,Methyl CpG binding protein 2 (Rett syndrome),Methyl CpG binding protein 2,Methyl-CpG-binding protein 2,MRX 16,MRX 79,MRX16,MRX79,MRXS 13,MRXS13,MRXSL,PPMX,RS,RTS,RTT,WBP 10,WBP10

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire:

Observed_MW: 83kDa

Calculated_MW: 52kDa/53kDa

ID gène: 4204

UniProt: P51608

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane