EBP anticorps

N° du produit ABIN6568497

Cet anticorps Lapin Polyclonal détecte spécifiquement EBP dans WB. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour EBP anticorps (ABIN6568497)

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EBP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EBP anticorps

Purification: Affinity purification

Immunogène: A synthetic peptide of human EBP

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur EBP

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Autre désignation: EBP

Sujet:

Synonyms: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase,CDPX2 ,CHO2,Cholestenol Delta-isomerase,CPX,CPXD,D8-D7 sterol isomerase,Delta(8)-Delta(7) sterol isomerase,ebp,EBP,Emopamil-binding protein,Msi

Background: The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).

Poids moléculaire:

Observed_MW: 26kDa

Calculated_MW: 26kDa

ID gène: 10682

UniProt: Q15125