SPAM1 anticorps
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- Antigène Voir toutes SPAM1 Anticorps
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SPAM1 est non-conjugé
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human SPAM1 (NP_003108.2).
- Isotype
- IgG
- Top Product
- Discover our top product SPAM1 Anticorps primaire
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- Indications d'application
- IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
- Autre désignation
- SPAM1 (SPAM1 Produits)
- Synonymes
- anticorps AV039194, anticorps Ph-20, anticorps PH-20, anticorps PH20, anticorps HYA1, anticorps HYAL1, anticorps HYAL3, anticorps HYAL5, anticorps SPAG15, anticorps Spam, anticorps XEH1, anticorps spam1, anticorps im:6902904, anticorps zgc:158668, anticorps sperm adhesion molecule 1, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding), anticorps Spam1, anticorps SPAM1, anticorps spam1.L, anticorps spam1
- Sujet
- Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
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Observed_MW: 47kDa
Calculated_MW: 57kDa/58kDa
- ID gène
- 6677
- UniProt
- P38567
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