Androgen Receptor anticorps (Center)

N° du produit ABIN656982

Cet anticorps anti-Androgen Receptor Polyclonal Lapin (Clone RB32967) (ABIN656982) détecte spécifiquement Androgen Receptor dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Androgen Receptor anticorps (Center) (ABIN656982)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB)

Clone: RB32967

Détail du produit anti-Androgen Receptor anticorps

Épitope: AA 282-309, Center

Specificité: This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the Central region of human AR.

Homologie: Monkey

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This AR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-309 AA from the Central region of human AR.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB = 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.33 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: AR Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: AR

Sujet: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq].
Synonyms: Androgen receptor,AR,DHTR, NR3C4

Poids moléculaire: 98989 DA

ID gène: 367

NCBI Accession: NP_001011645, NP_000035

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding